ANTIBACTERIAL ACTIVITY OF MEDICINAL PLANTS FROM BALOCHISTAN AGAINST MULTIDRUG RESISTANCE BACTERIA

Abstract

The emergence of antibiotic resistance bacteria and diseases caused becoming the major health concern globally. The effective treatment for bacterial infections includes a variety of drugs that makes it necessary to know about the potential source of these drugs. The medicinal herbs used by local community of Quetta Balochistan, can be explored as a source to fight against disease caused by bacteria. This study aims to identify antibacterial activity of: Berberis baluchistanica, Solanum nigrum, Trachyspermum ammi, Trigonella foenum-graecum, Anogeissus latifolia, E. coli, S. aureus, and P. aeruginosa (caused hospital acquired infection). Crude ethanolic plant extract was used by agar well diffusion method. The results showed T. Ammi, A. latifolia, B. Baluchistanica and S. Nigrum showed maximum zone of inhibition (ZOI) against E. coli (19.3mm, 18.3, 15.7mm, and 15.1mm), S. aureus (20.7mm, 18.3mm, 15.1mm and 12.3mm) while T. foenum-graecum showed minimum ZOI against E. coli (4.4mm) and S. aureus (3.8mm). Moreover, it was observed that extracts of B. Baluchistanica and A. latifolia were effective against P. aeruginosa with ZOI 8.6mm and 9.2mm, a multi drug resistance (MDR) bacterium, which suggested that these extracts contain some bioactive compound required to inhibit the growth of MDR bacterium. This study confirmed that the efficacy of selected medicinal plant extracts as natural antibiotic medicine and recommended the use of these plants to treat infectious diseases.